Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations.

@article{Pankratz2002GenomeST,
  title={Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations.},
  author={Nathan Pankratz and William C. Nichols and Sean K Uniacke and Cheryl A Halter and Alice Rudolph and Cliff W Shults and P. Michael Conneally and Tatiana Foroud},
  journal={American journal of human genetics},
  year={2002},
  volume={71 1},
  pages={124-35}
}
Parkinson disease (PD) is a common neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity, and postural instability, as well as by a clinically significant response to treatment with levodopa. Mutations in the alpha-synuclein gene have been found to result in autosomal dominant PD, and mutations in the parkin gene produce autosomal recessive juvenile-onset PD. We have studied 203 sibling pairs with PD who were evaluated by a rigorous neurological assessment… CONTINUE READING

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