Genome scanning detects amplification of the cathepsin B gene (CtsB) in transformed rat ovarian surface epithelial cells.

@article{Abdollahi1999GenomeSD,
  title={Genome scanning detects amplification of the cathepsin B gene (CtsB) in transformed rat ovarian surface epithelial cells.},
  author={Abbas Abdollahi and L A Getts and Gonosuke Sonoda and Paul E. Miller and T. Taguchi and Andrew K. Godwin and Joseph R Testa and Thomas C. Hamilton},
  journal={Journal of the Society for Gynecologic Investigation},
  year={1999},
  volume={6 1},
  pages={32-40}
}
OBJECTIVE To isolate a portion of the amplicon inferred to be present in a malignant rat tumor cell line, NuTu 26, by the presence of a homogeneously staining chromosomal region (hsr) and identify genes embedded within it. METHODS Genome scanning was used to identify an EcoRI fragment (8.6 kbp) within the amplified region of the NuTu 26 genome using a… CONTINUE READING