Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.

  title={Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.},
  author={Cathryn M. Lewis and Douglas F. Levinson and Lesley H Wise and Lynn E. DeLisi and Richard E Straub and Iiris Hovatta and Nigel W. Williams and Sibylle G. Schwab and Ann E Pulver and Stephen V Faraone and Linda Brzustowicz and Charles A Kaufmann and David L. Garver and Hugh Malcolm Douglas Gurling and Eva Lindholm and Hilary Coon and Hans Moises and William Byerley and Sarah H. Shaw and Andrea Mes{\'e}n and Robin Sherrington and Francis Anthony O'Neill and Dermot Walsh and Kenneth S. Kendler and J. Ekelund and Tiina Paunio and Jouko L{\"o}nnqvist and L. Peltonen and Michael C O'Donovan and Michael J Owen and Dieter D B Wildenauer and Wolfgang Maier and Gerald Nestadt and J. L. Blouin and Stylianos E. Antonarakis and B. J. Mowry and Jeremy M. Silverman and Raymond R. Crowe and C. Robert Cloninger and Ming T. Tsuang and Dolores Malaspina and Jill M Harkavy-Friedman and Dragan M. Svrakic and Anne S. Bassett and Jennifer M Holcomb and Gursharan Kalsi and Andrew McQuillin and Jon Brynjolfson and Thordur Sigmundsson and Hannes P{\'e}tursson and Elena Jazin and T{\'o}mas Zo{\"e}ga and T{\'o}mas Helgason},
  journal={American journal of human genetics},
  volume={73 1},
Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across… CONTINUE READING
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