Genome-scale profiling of histone H3.3 replacement patterns

@article{Mito2005GenomescalePO,
  title={Genome-scale profiling of histone H3.3 replacement patterns},
  author={Yoshiko Mito and Jorja G. Henikoff and Steven Henikoff},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={1090-1097}
}
Histones of multicellular organisms are assembled into chromatin primarily during DNA replication. When chromatin assembly occurs at other times, the histone H3.3 variant replaces canonical H3. Here we introduce a new strategy for profiling epigenetic patterns on the basis of H3.3 replacement, using microarrays covering roughly one-third of the Drosophila melanogaster genome at 100-bp resolution. We identified patterns of H3.3 replacement over active genes and transposons. H3.3 replacement… CONTINUE READING
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