Genome-scale models of microbial cells: evaluating the consequences of constraints

@article{Price2004GenomescaleMO,
  title={Genome-scale models of microbial cells: evaluating the consequences of constraints},
  author={Nathan D. Price and Jennifer L. Reed and Bernhard O. Palsson},
  journal={Nature Reviews Microbiology},
  year={2004},
  volume={2},
  pages={886-897}
}
Microbial cells operate under governing constraints that limit their range of possible functions. With the availability of annotated genome sequences, it has become possible to reconstruct genome-scale biochemical reaction networks for microorganisms. The imposition of governing constraints on a reconstructed biochemical network leads to the definition of achievable cellular functions. In recent years, a substantial and growing toolbox of computational analysis methods has been developed to… 

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