Genome-scale gene/reaction essentiality and synthetic lethality analysis

@article{Suthers2009GenomescaleGE,
  title={Genome-scale gene/reaction essentiality and synthetic lethality analysis},
  author={Patrick F. Suthers and Alireza Zomorrodi and Costas D. Maranas},
  journal={Molecular Systems Biology},
  year={2009},
  volume={5},
  pages={301 - 301}
}
Synthetic lethals are to pairs of non-essential genes whose simultaneous deletion prohibits growth. One can extend the concept of synthetic lethality by considering gene groups of increasing size where only the simultaneous elimination of all genes is lethal, whereas individual gene deletions are not. We developed optimization-based procedures for the exhaustive and targeted enumeration of multi-gene (and by extension multi-reaction) lethals for genome-scale metabolic models. Specifically… CONTINUE READING
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