Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features.

@article{Cayrou2011GenomescaleAO,
  title={Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features.},
  author={Christelle Cayrou and Philippe Coulombe and Alice Vigneron and Slavica Stanojcic and Olivier Ganier and Isabelle Peiffer and Eric Rivals and Aurore Puy and Sabine Laurent-Chabalier and Romain Desprat and Marcel M{\'e}chali},
  journal={Genome research},
  year={2011},
  volume={21 9},
  pages={1438-49}
}
In metazoans, thousands of DNA replication origins (Oris) are activated at each cell cycle. Their genomic organization and their genetic nature remain elusive. Here, we characterized Oris by nascent strand (NS) purification and a genome-wide analysis in Drosophila and mouse cells. We show that in both species most CpG islands (CGI) contain Oris, although methylation is nearly absent in Drosophila, indicating that this epigenetic mark is not crucial for defining the activated origin. Initiation… CONTINUE READING
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