Genome replication engineering assisted continuous evolution (GREACE) to improve microbial tolerance for biofuels production

@inproceedings{Luan2013GenomeRE,
  title={Genome replication engineering assisted continuous evolution (GREACE) to improve microbial tolerance for biofuels production},
  author={Guodong Luan and Zhen Cai and Yin Li and Yanhe Ma},
  booktitle={Biotechnology for biofuels},
  year={2013}
}
BACKGROUND Microbial production of biofuels requires robust cell growth and metabolism under tough conditions. Conventionally, such tolerance phenotypes were engineered through evolutionary engineering using the principle of "Mutagenesis followed-by Selection". The iterative rounds of mutagenesis-selection and frequent manual interventions resulted in discontinuous and inefficient strain improvement processes. This work aimed to develop a more continuous and efficient evolutionary engineering… CONTINUE READING

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