Genome reference and sequence variation in the large repetitive central exon of human MUC5AC.

@article{Guo2014GenomeRA,
  title={Genome reference and sequence variation in the large repetitive central exon of human MUC5AC.},
  author={Xueliang Guo and Shuo Zheng and Hong V T Dang and Rhonda G. Pace and Jaclyn R. Stonebraker and Corbin D. Jones and Frank Boellmann and George Yuan and Prashamsha Haridass and Olivier Fedrigo and David L. Corcoran and Max A. Seibold and Swati S. Ranade and Michael R Knowles and Wanda K. O'Neal and Judith A Voynow},
  journal={American journal of respiratory cell and molecular biology},
  year={2014},
  volume={50 1},
  pages={223-32}
}
Despite modern sequencing efforts, the difficulty in assembly of highly repetitive sequences has prevented resolution of human genome gaps, including some in the coding regions of genes with important biological functions. One such gene, MUC5AC, encodes a large, secreted mucin, which is one of the two major secreted mucins in human airways. The MUC5AC region contains a gap in the human genome reference (hg19) across the large, highly repetitive, and complex central exon. This exon is predicted… CONTINUE READING
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