Genome organization and long-range regulation of gene expression by enhancers.

@article{Smallwood2013GenomeOA,
  title={Genome organization and long-range regulation of gene expression by enhancers.},
  author={Andrea Smallwood and Bing Ren},
  journal={Current opinion in cell biology},
  year={2013},
  volume={25 3},
  pages={387-94}
}
It is now well accepted that cell-type specific gene regulation is under the purview of enhancers. Great strides have been made recently to characterize and identify enhancers both genetically and epigenetically for multiple cell types and species, but efforts have just begun to link enhancers to their target promoters. Mapping these interactions and understanding how the 3D landscape of the genome constrains such interactions is fundamental to our understanding of mammalian gene regulation… CONTINUE READING

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