Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

  title={Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling},
  author={Michael Clarke and Amanda J. Lohan and Bernard A. Liu and Ilias Lagkouvardos and Scott William Roy and Nikhat Zafar and Claire Bertelli and Christina Schilde and Arash Kianianmomeni and Thomas R. B{\"u}rglin and Christian Frech and Bernard Turcotte and Klaus O. Kopec and John M. Synnott and Caleb Choo and Ivan A. Paponov and Aliza Finkler and Chris Soon Heng Tan and Andrew P Hutchins and Thomas Weinmeier and Thomas Rattei and Jeffrey Shih-Chieh Chu and Gr{\'e}gory Gimenez and Manuel Irimia and Daniel J. Rigden and David A Fitzpatrick and Jacob Lorenzo-Morales and Alex Bateman and C. H. Chiu and Petrus Tang and Peter Hegemann and Hillel Fromm and Didier Raoult and Gilbert Greub and Diego Miranda-Saavedra and Nansheng Chen and Piers Nash and Michael L. Ginger and Matthias Horn and Pauline Schaap and Lis Caler and Brendan J. Loftus},
  booktitle={Genome Biology},
The Amoebozoa constitute one of the primary divisions of eukaryotes, encompassing taxa of both biomedical and evolutionary importance, yet its genomic diversity remains largely unsampled. Here we present an analysis of a whole genome assembly of Acanthamoeba castellanii (Ac) the first representative from a solitary free-living amoebozoan. Ac encodes 15,455 compact intron-rich genes, a significant number of which are predicted to have arisen through inter-kingdom lateral gene transfer (LGT). A… CONTINUE READING
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RuizTrillo I: Genomic survey of premetazoans shows deep conservation of cytoplasmic tyrosine kinases and multiple radiations of receptor tyrosine kinases

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