Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles.

@article{Hayashi2014GenomeMR,
  title={Genome mining reveals a minimum gene set for the biosynthesis of 32-membered macrocyclic thiopeptides lactazoles.},
  author={Shohei Hayashi and Taro Ozaki and Shumpei Asamizu and Haruo Ikeda and Satoshi O̅mura and Naoya Oku and Yasuhiro Igarashi and Hiroshi Tomoda and Hiroyasu Onaka},
  journal={Chemistry & biology},
  year={2014},
  volume={21 5},
  pages={679-88}
}
Although >100 thiopeptides have been discovered, the number of validated gene clusters involved in their biosynthesis is lagging. We use genome mining to identify a silent thiopeptide biosynthetic gene cluster responsible for biosynthesis of lactazoles. Lactazoles are structurally unique thiopeptides with a 32-membered macrocycle and a 2-oxazolyl-6-thiazolyl pyridine core. We demonstrate that lactazoles originate from the simplest cluster, containing only six unidirectional genes (lazA to lazF… CONTINUE READING
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