Genome mining and functional genomics for siderophore production in Aspergillus niger.

  title={Genome mining and functional genomics for siderophore production in Aspergillus niger.},
  author={Angelique C. W. Franken and Beatrix Elisabeth Lechner and Ernst R Werner and Hubertus Haas and B. Christien Lokman and Arthur F. J. Ram and Cees A. M. J. J. van den Hondel and Sandra de Weert and Peter J. Punt},
  journal={Briefings in functional genomics},
  volume={13 6},
Iron is an essential metal for many organisms, but the biologically relevant form of iron is scarce because of rapid oxidation resulting in low solubility. Simultaneously, excessive accumulation of iron is toxic. Consequently, iron uptake is a highly controlled process. In most fungal species, siderophores play a central role in iron handling. Siderophores are small iron-specific chelators that can be secreted to scavenge environmental iron or bind intracellular iron with high affinity. A… CONTINUE READING
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