Genome methylation patterns in male breast cancer – Identification of an epitype with hypermethylation of polycomb target genes

@inproceedings{Johansson2015GenomeMP,
  title={Genome methylation patterns in male breast cancer – Identification of an epitype with hypermethylation of polycomb target genes},
  author={Ida Johansson and Martin Lauss and Karolina Holm and Johan Staaf and Cecilia Nilsson and M L Fj{\"a}llskog and Markus Ringn{\'e}r and Ingrid Hedenfalk},
  booktitle={Molecular oncology},
  year={2015}
}
Male breast cancer (MBC) is a rare disease that shares both similarities and differences with female breast cancer (FBC). The aim of this study was to assess genome-wide DNA methylation profiles in MBC and compare them with the previously identified transcriptional subgroups of MBC, luminal M1 and M2, as well as the intrinsic subtypes of FBC. Illumina's 450K Infinium arrays were applied to 47 MBC and 188 FBC tumors. Unsupervised clustering of the most variable CpGs among MBC tumors revealed two… CONTINUE READING
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