Genome maintenance mechanisms for preventing cancer

@article{Hoeijmakers2001GenomeMM,
  title={Genome maintenance mechanisms for preventing cancer},
  author={J. Hoeijmakers},
  journal={Nature},
  year={2001},
  volume={411},
  pages={366-374}
}
  • J. Hoeijmakers
  • Published 2001
  • Biology, Medicine
  • Nature
  • The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly… CONTINUE READING
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