Genome location and identification of functions defective in the Bartha vaccine strain of pseudorabies virus.

@article{Lomniczi1987GenomeLA,
  title={Genome location and identification of functions defective in the Bartha vaccine strain of pseudorabies virus.},
  author={B{\'e}la Lomniczi and Shinji Watanabe and TAMAR BEN-PORAT and Albert S. Kaplan},
  journal={Journal of virology},
  year={1987},
  volume={61 3},
  pages={796-801}
}
We have shown previously (Lomniczi et al., J. Virol. 52:198-205, 1984) that the Bartha vaccine strain of pseudorabies virus has a deletion in the short unique (Us) region of its genome--a deletion that is related to the absence of virus virulence. This strain is, however, also defective in other genes involved in virulence. We show here that virulence can be restored by marker rescue of the Bartha strain to which an intact Us has been restored (but not to the parental Bartha strain) by… CONTINUE READING

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