Genome hyperevolution and the success of a parasite

  title={Genome hyperevolution and the success of a parasite},
  author={J. D. Barry and James P J Hall and Lindsey J Plenderleith},
  booktitle={Annals of the New York Academy of Sciences},
The strategy of antigenic variation is to present a constantly changing population phenotype that enhances parasite transmission, through evasion of immunity arising within, or existing between, host animals. Trypanosome antigenic variation occurs through spontaneous switching among members of a silent archive of many hundreds of variant surface glycoprotein (VSG) antigen genes. As with such contingency systems in other pathogens, switching appears to be triggered through inherently unstable… CONTINUE READING