Genome evolution and adaptation in a long-term experiment with Escherichia coli

@article{Barrick2009GenomeEA,
  title={Genome evolution and adaptation in a long-term experiment with Escherichia coli},
  author={Jeffrey E. Barrick and Dong Su Yu and Sung Ho Yoon and Haeyoung Jeong and Tae Kwang Oh and Dominique Schneider and Richard E. Lenski and Jihyun F. Kim},
  journal={Nature},
  year={2009},
  volume={461},
  pages={1243-1247}
}
The relationship between rates of genomic evolution and organismal adaptation remains uncertain, despite considerable interest. The feasibility of obtaining genome sequences from experimentally evolving populations offers the opportunity to investigate this relationship with new precision. Here we sequence genomes sampled through 40,000 generations from a laboratory population of Escherichia coli. Although adaptation decelerated sharply, genomic evolution was nearly constant for 20,000… Expand

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