Genome editing with engineered zinc finger nucleases

@article{Urnov2010GenomeEW,
  title={Genome editing with engineered zinc finger nucleases},
  author={F. Urnov and E. Rebar and M. Holmes and H. Zhang and P. Gregory},
  journal={Nature Reviews Genetics},
  year={2010},
  volume={11},
  pages={636-646}
}
Reverse genetics in model organisms such as Drosophila melanogaster, Arabidopsis thaliana, zebrafish and rats, efficient genome engineering in human embryonic stem and induced pluripotent stem cells, targeted integration in crop plants, and HIV resistance in immune cells — this broad range of outcomes has resulted from the application of the same core technology: targeted genome cleavage by engineered, sequence-specific zinc finger nucleases followed by gene modification during subsequent… Expand
1,648 Citations
Genome engineering in human cells.
  • 9
Targeted genome engineering via zinc finger nucleases
  • S. Kim, J. Kim
  • Medicine, Biology
  • Plant Biotechnology Reports
  • 2010
  • 16
  • PDF
Targeted Genome Editing Across Species Using ZFNs and TALENs
  • 568
  • PDF
Genome-Editing Technologies: Principles and Applications.
  • 77
  • PDF
Genome Editing in Stem Cells for Disease Therapeutics
  • 5
  • Highly Influenced
Mouse Genome Engineering Using Designer Nucleases
  • 15
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 106 REFERENCES
Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases
  • 857
  • PDF
Targeted mutagenesis using zinc-finger nucleases in Arabidopsis.
  • 353
  • PDF
Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases
  • 839
  • PDF
Generation of a triple‐gene knockout mammalian cell line using engineered zinc‐finger nucleases
  • 109
High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases
  • 302
  • PDF
...
1
2
3
4
5
...