Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

@inproceedings{Lin2014GenomeDO,
  title={Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations},
  author={Yao-Cheng Lin and Morgane Boone and Leander Meuris and Irma Lemmens and Nadine Van Roy and Arne Soete and Joke Reumers and Matthieu Moisse and St{\'e}phane Plaisance and R. Drmanac and Jason V. Chen and Frank Speleman and Diether Lambrechts and Yves Van de Peer and Jan Tavernier and Nico 3 Callewaert},
  booktitle={Nature communications},
  year={2014}
}
The HEK293 human cell lineage is widely used in cell biology and biotechnology. Here we use whole-genome resequencing of six 293 cell lines to study the dynamics of this aneuploid genome in response to the manipulations used to generate common 293 cell derivatives, such as transformation and stable clone generation (293T); suspension growth adaptation (293S); and cytotoxic lectin selection (293SG). Remarkably, we observe that copy number alteration detection could identify the genomic region… CONTINUE READING
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