Genome dynamics in Legionella: the basis of versatility and adaptation to intracellular replication.

  title={Genome dynamics in Legionella: the basis of versatility and adaptation to intracellular replication.},
  author={Laura Gomez-Valero and Carmen Buchrieser},
  journal={Cold Spring Harbor perspectives in medicine},
  volume={3 6}
Legionella pneumophila is a bacterial pathogen present in aquatic environments that can cause a severe pneumonia called Legionnaires' disease. Soon after its recognition, it was shown that Legionella replicates inside amoeba, suggesting that bacteria replicating in environmental protozoa are able to exploit conserved signaling pathways in human phagocytic cells. Comparative, evolutionary, and functional genomics suggests that the Legionella-amoeba interaction has shaped this pathogen more than… 

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