Genome damage in induced pluripotent stem cells: assessing the mechanisms and their consequences.

@article{Hussein2013GenomeDI,
  title={Genome damage in induced pluripotent stem cells: assessing the mechanisms and their consequences.},
  author={Samer Hussein and Judith Elbaz and Andras A Nagy},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2013},
  volume={35 3},
  pages={152-62}
}
In 2006, Shinya Yamanaka and colleagues discovered how to reprogram terminally differentiated somatic cells to a pluripotent stem cell state. The resulting induced pluripotent stem cells (iPSCs) made a paradigm shift in the field, further nailing down the disproval of the long-held dogma that differentiation is unidirectional. The prospect of using iPSCs for patient-specific cell-based therapies has been enticing. This promise, however, has been questioned in the last two years as several… CONTINUE READING
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