Genome-based and transcriptome-based molecular classification of breast cancer.

@article{Biche2011GenomebasedAT,
  title={Genome-based and transcriptome-based molecular classification of breast cancer.},
  author={Ivan Bi{\'e}che and Rosette Lidereau},
  journal={Current opinion in oncology},
  year={2011},
  volume={23 1},
  pages={93-9}
}
PURPOSE OF REVIEW The highly heterogeneous clinical, histological, biological and genetic nature of breast malignancies is due in part to their extreme molecular complexity. RECENT FINDINGS Many genetic and epigenetic alterations have been described, affecting a relatively small number of signaling pathways (PI3K, NK-κB, FGF, etc.) and thus several molecular subtypes of breast cancer have been identified. SUMMARY The next decade will see even more prolific developments, notably with the… CONTINUE READING