Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex.

@article{Jasiak2008GenomeassociatedRP,
  title={Genome-associated RNA polymerase II includes the dissociable Rpb4/7 subcomplex.},
  author={Anna J Jasiak and Holger Hartmann and Elena Karakasili and Marian Kalocsay and Andrew Flatley and Elisabeth Kremmer and Katja Straesser and Dietmar E. Martin and Johannes S{\"o}ding and Patrick Cramer},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 39},
  pages={26423-7}
}
Yeast RNA polymerase (Pol) II consists of a 10-subunit core enzyme and the Rpb4/7 subcomplex, which is dispensable for catalytic activity and dissociates in vitro. To investigate whether Rpb4/7 is an integral part of DNA-associated Pol II in vivo, we used chromatin immunoprecipitation coupled to high resolution tiling microarray analysis. We show that the genome-wide occupancy profiles for Rpb7 and the core subunit Rpb3 are essentially identical. Thus, the complete Pol II associates with DNA in… CONTINUE READING

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NUMBER 39 JOURNAL OF BIOLOGICAL CHEMISTRY 26427 at M ax Panck Ist.B iophikalische C em e,O tto H hn B ibl,P41,37018

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