Genome analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of the etiologic agent of tuberculosis

  title={Genome analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of the etiologic agent of tuberculosis},
  author={Philip Supply and Michael Marceau and Sophie Mangenot and David Roche and Carine Rouanet and Varun Khanna and Laleh Majlessi and Alexis Criscuolo and Julien Tap and Alexandre Pawlik and Laurence Fiette and Mickael Orgeur and Michel Fabre and C{\'e}cile Parmentier and Wafa Frigui and Roxane Sim{\'e}one and Eva C. Boritsch and A S Debrie and Eve Willery and Danielle L Walker and Michael A. Quail and Laurence Ma and Christiane Bouchier and Gregory Salvignol and Fadel Sayes and Alessandro Cascioferro and Torsten Seemann and Val{\'e}rie Barbe and Camille Locht and M Gutierrez and Claude Leclerc and Stephen D. Bentley and Timothy P Stinear and Sylvain Brisse and Claudine M{\'e}digue and Julian Parkhill and St{\'e}phane Cruveiller and Roland Brosch},
  booktitle={Nature Genetics},
Global spread and limited genetic variation are hallmarks of M. tuberculosis, the agent of human tuberculosis. In contrast, Mycobacterium canettii and related tubercle bacilli that also cause human tuberculosis and exhibit unusual smooth colony morphology are restricted to East Africa. Here, we sequenced and analyzed the whole genomes of five representative strains of smooth tubercle bacilli (STB) using Sanger (4–5× coverage), 454/Roche (13–18× coverage) and/or Illumina DNA sequencing (45–105… CONTINUE READING
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