Genome-Wide Stochastic Adaptive DNA Amplification at Direct and Inverted DNA Repeats in the Parasite Leishmania

@inproceedings{Ubeda2014GenomeWideSA,
  title={Genome-Wide Stochastic Adaptive DNA Amplification at Direct and Inverted DNA Repeats in the Parasite Leishmania},
  author={J. V. Ubeda and Fr{\'e}d{\'e}ric Raymond and Angana Mukherjee and Marie Plourde and H{\'e}l{\`e}ne Gingras and Ga{\'e}tan Du Roy and Andr{\'e}anne Lapointe and Philippe Leprohon and Barbara Papadopoulou and Jacques Corbeil and Marc A. Ouellette},
  booktitle={PLoS biology},
  year={2014}
}
Gene amplification of specific loci has been described in all kingdoms of life. In the protozoan parasite Leishmania, the product of amplification is usually part of extrachromosomal circular or linear amplicons that are formed at the level of direct or inverted repeated sequences. A bioinformatics screen revealed that repeated sequences are widely distributed in the Leishmania genome and the repeats are chromosome-specific, conserved among species, and generally present in low copy number… CONTINUE READING

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