Genome-Wide Screening of mRNA Expression in Leprosy Patients

  title={Genome-Wide Screening of mRNA Expression in Leprosy Patients},
  author={A. Belone and P. S. Rosa and A. Trombone and L. R. V. Fachin and C. Guidella and S. Ura and J. Barreto and M. Pinilla and A. F. de Carvalho and D. Carraro and F. A. Soares and C. Soares},
  journal={Frontiers in Genetics},
  • A. Belone, P. S. Rosa, +9 authors C. Soares
  • Published 2015
  • Medicine, Biology
  • Frontiers in Genetics
  • Leprosy, an infectious disease caused by Mycobacterium leprae, affects millions of people worldwide. However, little is known regarding its molecular pathophysiological mechanisms. In this study, a comprehensive assessment of human mRNA was performed on leprosy skin lesions by using DNA chip microarrays, which included the entire spectrum of the disease along with its reactional states. Sixty-six samples from leprotic lesions (10TT, 10BT, 10BB, 10BL, 4LL, 14R1, and 10R2) and nine skin biopsies… CONTINUE READING
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