Genome-Wide Screen for Salmonella Genes Required for Long-Term Systemic Infection of the Mouse

@article{Lawley2006GenomeWideSF,
  title={Genome-Wide Screen for Salmonella Genes Required for Long-Term Systemic Infection of the Mouse},
  author={Trevor D. Lawley and Kaman Chan and Lucinda J Thompson and Charles C. Kim and Gregory R. Govoni and Denise M Monack},
  journal={PLoS Pathogens},
  year={2006},
  volume={2},
  pages={7753 - 7757}
}
A microarray-based negative selection screen was performed to identify Salmonella enterica serovar Typhimurium (serovar Typhimurium) genes that contribute to long-term systemic infection in 129X1/SvJ (Nramp1(r)) mice. A high-complexity transposon-mutagenized library was used to infect mice intraperitoneally, and the selective disappearance of mutants was monitored after 7, 14, 21, and 28 d postinfection. One hundred and eighteen genes were identified to contribute to serovar Typhimurium… CONTINUE READING
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