Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling

@inproceedings{Utsunomiya2015GenomeWideSF,
  title={Genome-Wide Scan for Visceral Leishmaniasis in Mixed-Breed Dogs Identifies Candidate Genes Involved in T Helper Cells and Macrophage Signaling},
  author={Yuri Tani Utsunomiya and {\'E}rica Aparecida dos Santos Ribeiro and Amanda Pifano Neto Quintal and Juliano Rodrigues Sangalli and Valquiria R. Gazola and Henrique Borges de Paula and Cristiana M. Trinconi and V M F Lima and S{\'i}lvia Helena Venturoli Perri and Jeremy F. Taylor and Robert D. Schnabel and Tad S. Sonstegard and Jos{\'e} Fernando Garcia and C M Nunes and Dario S Zamboni},
  booktitle={PloS one},
  year={2015}
}
We conducted a genome-wide scan for visceral leishmaniasis in mixed-breed dogs from a highly endemic area in Brazil using 149,648 single nucleotide polymorphism (SNP) markers genotyped in 20 cases and 28 controls. Using a mixed model approach, we found two candidate loci on canine autosomes 1 and 2. The positional association on chromosome 2 mapped to a predicted DNAse sensitive site in CD14+ monocytes that serve as a cis-regulatory element for the expression of interleukin alpha receptors 2… CONTINUE READING