Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer’s Disease

  title={Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer’s Disease},
  author={Wan-Sheng Chang and Yonghong Wang and Xiao-Tun Zhu and Chuanjie Wu},
  booktitle={Medical science monitor : international medical journal of experimental and clinical research},
BACKGROUND Our study aimed to identify key differentially expressed genes (DEGs) and miRNAs (DEmiRNAs) which can serve as potential biomarkers for diagnosis and therapy of Alzheimer's disease (AD). MATERIAL AND METHODS We performed miRNA and mRNA integrated analysis (MMIA) to identify DEGs and DEmiRNAs of AD. The AD-specific DEmiRNAs-targets interaction network was contrasted. Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis were performed. Q-RT… CONTINUE READING
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