Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters

@article{Shen2007GenomeWidePO,
  title={Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters},
  author={Lanlan Shen and Yutaka Kondo and Yi Guo and Jiexin Zhang and Li Zhang and Saira Ahmed and Jingmin Shu and Xinli Chen and Robert A. Waterland and Jean-Pierre Issa},
  journal={PLoS Genetics},
  year={2007},
  volume={3},
  pages={209 - 213}
}
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal peripheral blood by methylated CpG island amplification in combination with microarrays. This technique allowed us to simultaneously determine the methylation status of 6,177 genes, 92% of which include dense CpG islands. Among these 5,549 autosomal genes with dense CpG island… CONTINUE READING

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