Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

@article{Poon2013GenomeWideMS,
  title={Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool},
  author={S. Poon and S. Pang and J. Mcpherson and Willie Yu and Kie Kyon Huang and P. Guan and W. Weng and E. Y. Siew and Yujing Liu and H. Heng and S. Chong and A. Gan and S. Tay and Weng Khong Lim and I. Cutcutache and Dachuan Huang and Lian Dee Ler and M. Nairism{\"a}gi and M. Lee and Ying-Hsu Chang and Kai-Jie Yu and W. Chan-on and Binkui Li and Yunfei Yuan and C. Qian and K. Ng and Chingfang Wu and Cheng‐Lung Hsu and R. Bunte and M. Stratton and P. A. Futreal and W. Sung and C. Chuang and C. Ong and S. Rozen and P. Tan and B. Teh},
  journal={Science Translational Medicine},
  year={2013},
  volume={5},
  pages={197ra101 - 197ra101}
}
Genome-wide mutational signatures of the group 1 carcinogen aristolochic acid are observed in urothelial cancers and liver cancers from Asia. Carcinogen AAlert Aristolochic acid (AA) is a natural compound derived from plants in the Aristolochia genus. For centuries, Aristolochia has been used throughout Asia to treat a variety of ailments as a component of traditional Chinese medicine. In recent years, however, a more sinister side of this herb has come to light when it was linked to kidney… Expand
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