Genome Wide Methylome Alterations in Lung Cancer.

@article{Mullapudi2015GenomeWM,
  title={Genome Wide Methylome Alterations in Lung Cancer.},
  author={Nandita Mullapudi and B Hilda Ye and Masako Suzuki and Melissa J. Fazzari and Weiguo Han and Miao Shi and Gaby Marquardt and Juan Lin and Tao Wang and Steven M. Keller and Changcheng Zhu and Joseph D. Locker and SimonD. Spivack},
  journal={PloS one},
  year={2015},
  volume={10 12},
  pages={
          e0143826
        }
}
Aberrant cytosine 5-methylation underlies many deregulated elements of cancer. Among paired non-small cell lung cancers (NSCLC), we sought to profile DNA 5-methyl-cytosine features which may underlie genome-wide deregulation. In one of the more dense interrogations of the methylome, we sampled 1.2 million CpG sites from twenty-four NSCLC tumor (T)-non-tumor (NT) pairs using a methylation-sensitive restriction enzyme- based HELP-microarray assay. We found 225,350 differentially methylated (DM… CONTINUE READING
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