Genome-Wide Mapping of Furfural Tolerance Genes in Escherichia coli

  title={Genome-Wide Mapping of Furfural Tolerance Genes in Escherichia coli},
  author={Tirzah Y. Glebes and Nicholas R Sandoval and Philippa J. Reeder and Katherine D. Schilling and Min Zhang and Ryan T. Gill},
  booktitle={PloS one},
Advances in genomics have improved the ability to map complex genotype-to-phenotype relationships, like those required for engineering chemical tolerance. Here, we have applied the multiSCale Analysis of Library Enrichments (SCALEs; Lynch et al. (2007) Nat. Method.) approach to map, in parallel, the effect of increased dosage for >10(5) different fragments of the Escherichia coli genome onto furfural tolerance (furfural is a key toxin of lignocellulosic hydrolysate). Only 268 of >4,000 E. coli… CONTINUE READING

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