Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile

@inproceedings{Soutourina2013GenomeWideIO,
  title={Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile},
  author={Olga Soutourina and Marc Monot and Pierre M. Boudry and Laure Saujet and Christophe Pichon and Odile Sismeiro and Ekaterina Semenova and Konstantin Severinov and Chantal Le Bougu{\'e}nec and J Y Copp{\'e}e and Bruno Dupuy and Isabelle Martin-Verstraete},
  booktitle={PLoS genetics},
  year={2013}
}
Clostridium difficile is an emergent pathogen, and the most common cause of nosocomial diarrhea. In an effort to understand the role of small noncoding RNAs (sRNAs) in C. difficile physiology and pathogenesis, we used an in silico approach to identify 511 sRNA candidates in both intergenic and coding regions. In parallel, RNA-seq and differential 5'-end RNA-seq were used for global identification of C. difficile sRNAs and their transcriptional start sites at three different growth conditions… CONTINUE READING

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