Genome-Wide Heterogeneity of Nucleotide Substitution Model Fit

@inproceedings{Arbiza2011GenomeWideHO,
  title={Genome-Wide Heterogeneity of Nucleotide Substitution Model Fit},
  author={Leonardo Arbiza and Mateus Patricio and Hern{\'a}n Dopazo and David Posada},
  booktitle={Genome biology and evolution},
  year={2011}
}
At a genomic scale, the patterns that have shaped molecular evolution are believed to be largely heterogeneous. Consequently, comparative analyses should use appropriate probabilistic substitution models that capture the main features under which different genomic regions have evolved. While efforts have concentrated in the development and understanding of model selection techniques, no descriptions of overall relative substitution model fit at the genome level have been reported. Here, we… CONTINUE READING
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