Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis

@inproceedings{Ottenhoff2012GenomeWideEP,
  title={Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active Tuberculosis},
  author={Tom H. M. Ottenhoff and Ranjeeta Hari Dass and Ninghan Yang and Mingzi M. Zhang and Hazel En En Wong and Edhyana Sahiratmadja and Chiea Chuen Khor and Bachti Alisjahbana and Reinout van Crevel and Sangkot Marzuki and Mark Seielstad and Esther van de Vosse and Martin L. Hibberd},
  booktitle={PloS one},
  year={2012}
}
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains the leading cause of mortality from a single infectious agent. Each year around 9 million individuals newly develop active TB disease, and over 2 billion individuals are latently infected with M.tb worldwide, thus being at risk of developing TB reactivation disease later in life. The underlying mechanisms and pathways of protection against TB in humans, as well as the dynamics of the host response to M.tb infection, are… CONTINUE READING

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