Genome-Wide DNA Methylation Profiles Indicate CD8+ T Cell Hypermethylation in Multiple Sclerosis

@inproceedings{Bos2015GenomeWideDM,
  title={Genome-Wide DNA Methylation Profiles Indicate CD8+ T Cell Hypermethylation in Multiple Sclerosis},
  author={Steffan Daniel Bos and Christian M Page and Bettina K. Andreassen and Emon Elboudwarej and Marte Wendel Gustavsen and Farren B.S. Briggs and Hong Quach and Ingvild S\orum Leikfoss and Anja Bj\olgerud and Tone Berge and Hanne F. Harbo and Lisa F. Barcellos},
  booktitle={PloS one},
  year={2015}
}
OBJECTIVE Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients. METHODS Whole blood, CD4+ and CD8+ T cell DNA from 16 female, treatment naïve MS patients and 14 matched controls was profiled using the HumanMethylation450K BeadChip. Genotype data were used to assess genetic homogeneity of our sample and to exclude potential SNP-induced DNA methylation measurement errors. RESULTS As expected, significant… CONTINUE READING
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