Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women

@inproceedings{Prescott2012GenomeWideAS,
  title={Genome-Wide Association Study of Circulating Estradiol, Testosterone, and Sex Hormone-Binding Globulin in Postmenopausal Women},
  author={Jennifer Prescott and Deborah J Thompson and Peter Kraft and Stephen J. Chanock and Tina Audley and Judith K Brown and Jean Leyland and Elizabeth J Folkerd and Deborah A Doody and Susan E. Hankinson and David J. Hunter and Kevin B. Jacobs and Mitch Dowsett and David G. Cox and Douglas F. Easton and Immaculata De Vivo},
  booktitle={PloS one},
  year={2012}
}
Genome-wide association studies (GWAS) have successfully identified common genetic variants that contribute to breast cancer risk. Discovering additional variants has become difficult, as power to detect variants of weaker effect with present sample sizes is limited. An alternative approach is to look for variants associated with quantitative traits that in turn affect disease risk. As exposure to high circulating estradiol and testosterone, and low sex hormone-binding globulin (SHBG) levels is… CONTINUE READING
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