Genome-Wide Association Study of Cell-Mediated Response in Dogs Naturally Infected by Leishmania infantum.

@article{Batista2016GenomeWideAS,
  title={Genome-Wide Association Study of Cell-Mediated Response in Dogs Naturally Infected by Leishmania infantum.},
  author={Lu{\'i}s F S Batista and Yuri Tani Utsunomiya and Tha{\'i}s B. F. Silva and Ra{\'i}ssa A Dias and Thaise Yumie Tomokane and Ac{\'a}cio Duarte Pacheco and V{\^a}nia L{\'u}cia Ribeiro da Matta and Fernando Tobias Silveira and Mary Marcondes and C M Nunes and Marcia Dalastra Laurenti},
  journal={Infection and immunity},
  year={2016},
  volume={84 12},
  pages={3629-3637}
}
A genome-wide association study (GWAS) could unravel the complexity of the cell-mediated immunity (CMI) to canine leishmaniasis (CanL). Therefore, we scanned 110,165 single-nucleotide polymorphisms (SNPs), aiming to identify chromosomal regions associated with the leishmanin skin test (LST), lymphocyte proliferation assay (LPA), and cytokine responses to further understand the role played by CMI in the outcome of natural Leishmania infantum infection in 189 dogs. Based on LST and LPA, four CMI… CONTINUE READING
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