Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis

@inproceedings{Hager2012GenomeWideAS,
  title={Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis},
  author={J{\"o}rg Hager and Yoichiro Kamatani and Jean-Baptiste Cazier and Sonia Youhanna and Michella Ghassibe-Sabbagh and Daniel E. Platt and Antoine Abchee and Jihane Romanos and Georges Khazen and Raed Othman and Danielle A. Badro and Marc Haber and Angelique K. Salloum and Bouchra Douaihy and Nabil Shasha and Samer Kabbani and Hana Sbeite and Elie Chammas and Hamid el Bayeh and Francis Rousseau and Diana Z{\'e}l{\'e}nika and Ivo G Gut and Mark Lathrop and Martin Farrall and Dominique Gauguier and Pierre A. Zalloua},
  booktitle={PloS one},
  year={2012}
}
The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are a crucial step in understanding global CAD pathophysiology. In this study, we report a GWAS on the genetic basis of arterial stenosis as measured by cardiac catheterization in a… CONTINUE READING
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A genome - wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

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