Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension

@inproceedings{Liu2016GenomeWA,
  title={Genome Wide Association Study Identifies L3MBTL4 as a Novel Susceptibility Gene for Hypertension},
  author={Xin Liu and Cheng Hu and Minghui Bao and Jing Li and Xiaoyan Liu and Xuerui Tan and Yong Zhou and Yequn Chen and Shouling Wu and Shuohua Chen and Rong Zhang and Feng Jiang and Weiping Jia and Xingyu Wang and Xinchun Yang and Jun Cai},
  booktitle={Scientific reports},
  year={2016}
}
Hypertension is a major global health burden and a leading risk factor for cardiovascular diseases. Although its heritability has been documented previously, contributing loci identified to date account for only a small fraction of blood pressure (BP) variation, which strongly suggests the existence of undiscovered variants. To identify novel variants, we conducted a three staged genetic study in 21,990 hypertensive cases and normotensive controls. Four single nucleotide polymorphisms (SNPs) at… CONTINUE READING
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