Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

  title={Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution},
  author={Cecilia M. Lindgren and Iris M. Heid and Joshua C. Randall and Claudia Lamina and Valgerdur Steinthorsdottir and Lu Qi and Elizabeth K. Speliotes and Gudmar Thorleifsson and Cristen J. Willer and Blanca Marcela Herrera and Anne U. Jackson and Noha Lim and Paul Scheet and Nicole Soranzo and Najaf Amin and Yurii S. Aulchenko and John Campbell Chambers and Alexander Drong and Jian'an Luan and Helen N. Lyon and Fernando Rivadeneira and Serena Sanna and Nicholas J. Timpson and M C Carola Zillikens and Jing Hua Zhao and Peter Almgren and Stefania Bandinelli and Amanda J. Bennett and Richard N Bergman and Lori L. Bonnycastle and Suzannah J. Bumpstead and Stephen J. Chanock and Lynn Cherkas and Peter S. Chines and Lachlan Coin and Cyrus Cooper and Gabriel J. Crawford and Angela D{\"o}ring and Anna A. Dominiczak and Alex S. F. Doney and Shah Ebrahim and Paul Elliott and Michael R Erdos and Karol Estrada and Luigi Ferrucci and Guido Fischer and Nita G Forouhi and Christian Gieger and Harald Grallert and Christopher James Groves and Scott Grundy and Candace Guiducci and David Hadley and Anders Hamsten and Aki S. Havulinna and Albert Hofman and Rolf Holle and John W Holloway and Thomas Illig and Bo Isomaa and Leonie C. Jacobs and Karen Jameson and Pekka J Jousilahti and Fredrik Karpe and Johanna Kuusisto and Jaana H. Laitinen and G. M. Lathrop and Debbie A Lawlor and Massimo Mangino and Wendy L. Mcardle and Thomas Meitinger and Mario A. Morken and Andrew P. Morris and Patricia B. Munroe and Narisu Narisu and Anna Nordstr{\"o}m and Peter Nordstr{\"o}m and Ben A. Oostra and Colin N A Palmer and Felicity Payne and John F. Peden and Inga Prokopenko and Frida Renstr{\"o}m and Aimo O Ruokonen and Veikko V Salomaa and Manjinder S. Sandhu and Laura J. Scott and Angelo Scuteri and Kaisa Silander and Kijoung Song and Xin Yuan and Heather M Stringham and Amy J. Swift and Tiinamaija Tuomi and Manuela Uda and Peter Vollenweider and G{\'e}rard Waeber and Chris Wallace and G Bragi Walters and M. N. Weedon and Jacqueline C. M. Witteman and Cuilin Zhang and Weihua Zhang and Mark J. Caulfield and Francis S. Collins and George Davey Smith and I. N. Day and Paul W Franks and Andrew T Hattersley and Frank B Hu and Marjo-Riitta Jarvelin and Augustine Kong and Jaspal Singh Kooner and Markku Laakso and Edward G. Lakatta and Vincent Mooser and Andrew D. Morris and Leena Peltonen and Nilesh J. Samani and Tim D. Spector and David P. Strachan and Toshiko Tanaka and Jaakko Tuomilehto and Andr{\'e} G. Uitterlinden and Cornelia M van Duijn and Nicholas J Wareham and Hugh Watkins for the PROCARDIS consortia and Dawn Waterworth and Michael Boehnke and Panagiotis Deloukas and Leif Groop and David J. Hunter and Unnur Thorsteinsdottir and David Schlessinger and H Erich Wichmann and Timothy M. Frayling and Gonçalo R. Abecasis and Joel Hirschhorn and Ruth J. F. Loos and K{\'a}ri Stef{\'a}nsson and Karen L. Mohlke and In{\^e}s Barroso and Mark I. McCarthy for the GIANT consortium},
  journal={PLoS Genetics},
  pages={2105 - 2120}
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two… CONTINUE READING
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