Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

@inproceedings{Speliotes2011GenomeWideAA,
  title={Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits},
  author={Elizabeth K. Speliotes and Laura M Yerges-Armstrong and Jun Wu and Ruben Hernaez and Lauren Kim and Cameron D. Palmer and Vilmundur Gudnason and Gudny Eir{\'i}ksdott{\'i}r and Melissa E. Garcia and Lenore J. Launer and Michael A. Nalls and Jeanne M Clark and Braxton D. Mitchell and Alan R. Shuldiner and Johannah L. Butler and Marta Tom{\'a}s and Udo Hoffmann and Shih-Jen Hwang and Joseph M. Massaro and Christopher J. O'Donnell and Dushyant V. Sahani and Veikko V Salomaa and Eric E. Schadt and Stephen M Schwartz and David S Siscovick and Benjamin F. Voight and John Jeffrey Carr and Mary F Feitosa and T. B. Harris and Caroline Fox and Albert Vernon Smith and W. H. Kao and Joel Hirschhorn and Ingrid B. Borecki},
  booktitle={PLoS genetics},
  year={2011}
}
Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we show that CT hepatic steatosis is heritable (∼26%-27%) in family-based Amish, Family… CONTINUE READING
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