Genome-Wide Analysis of Heteroduplex DNA in Mismatch Repair–Deficient Yeast Cells Reveals Novel Properties of Meiotic Recombination Pathways

@inproceedings{Martini2011GenomeWideAO,
  title={Genome-Wide Analysis of Heteroduplex DNA in Mismatch Repair–Deficient Yeast Cells Reveals Novel Properties of Meiotic Recombination Pathways},
  author={Emmanuelle Martini and Val{\'e}rie Borde and Matthieu Legendre and St{\'e}phane Audic and B{\'e}atrice Regnault and Guillaume Soubigou and Bernard Dujon and Bertrand Llorente},
  booktitle={PLoS genetics},
  year={2011}
}
Meiotic DNA double-strand breaks (DSBs) initiate crossover (CO) recombination, which is necessary for accurate chromosome segregation, but DSBs may also repair as non-crossovers (NCOs). Multiple recombination pathways with specific intermediates are expected to lead to COs and NCOs. We revisited the mechanisms of meiotic DSB repair and the regulation of CO formation, by conducting a genome-wide analysis of strand-transfer intermediates associated with recombination events. We performed this… CONTINUE READING

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References

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Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 6 Excerpts
Highly Influenced

Recombinational repair of gaps in DNA is asymmetric in Ustilago maydis and can be explained by a migrating D-loop model.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 8 Excerpts
Highly Influenced

Global analysis of the meiotic crossover landscape.

Developmental cell • 2008
View 8 Excerpts
Highly Influenced

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