Genome-Wide Analysis of Glucocorticoid Receptor Binding Regions in Adipocytes Reveal Gene Network Involved in Triglyceride Homeostasis

  title={Genome-Wide Analysis of Glucocorticoid Receptor Binding Regions in Adipocytes Reveal Gene Network Involved in Triglyceride Homeostasis},
  author={Chi-Yi Yu and Oleg Mayba and Joyce V. Lee and Joanna Tran and Charlie L Harris and T. Speed and J. Wang},
  journal={PLoS ONE},
  • Chi-Yi Yu, Oleg Mayba, +4 authors J. Wang
  • Published 2010
  • Biology, Medicine
  • PLoS ONE
  • Glucocorticoids play important roles in the regulation of distinct aspects of adipocyte biology. Excess glucocorticoids in adipocytes are associated with metabolic disorders, including central obesity, insulin resistance and dyslipidemia. To understand the mechanisms underlying the glucocorticoid action in adipocytes, we used chromatin immunoprecipitation sequencing to isolate genome-wide glucocorticoid receptor (GR) binding regions (GBRs) in 3T3-L1 adipocytes. Furthermore, gene expression… CONTINUE READING
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