Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes

@inproceedings{Behr2013GenomeWA,
  title={Genome Wide Analysis of Drug-Induced Torsades de Pointes: Lack of Common Variants with Large Effect Sizes},
  author={Elijah R Behr and Marylyn D. Ritchie and Toshihiro Tanaka and Stefan K{\"a}{\"a}b and Dana C. Crawford and Pa{\^o}la Corr{\^e}a Nicoletti and Aris Floratos and Moritz F. Sinner and Prince J. Kannankeril and Arthur A M Wilde and Connie R. Bezzina and Ellen Schulze-Bahr and Sven Zumhagen and Pascale Guicheney and Nanette Hahr Bishopric and Vanessa C. Marshall and Saad Mohd Shakir and Chrysoula Dalageorgou and Steve N Bevan and Yalda Jamshidi and Rachel Bastiaenen and Robert Jerome Myerburg and J. J. Schott and Alan John Camm and Gerhard Steinbeck and Kris J Norris and Russ B. Altman and Nicholas P. Tatonetti and S Horsburgh Jeffery and Michiaki Kubo and Yusuke Nakamura and Yufeng Shen and Alfred L. George and Dan M. Roden},
  booktitle={PloS one},
  year={2013}
}
Marked prolongation of the QT interval on the electrocardiogram associated with the polymorphic ventricular tachycardia Torsades de Pointes is a serious adverse event during treatment with antiarrhythmic drugs and other culprit medications, and is a common cause for drug relabeling and withdrawal. Although clinical risk factors have been identified, the syndrome remains unpredictable in an individual patient. Here we used genome-wide association analysis to search for common predisposing… CONTINUE READING

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