Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin.

@article{Poungvarin2015GenomeWideAO,
  title={Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin.},
  author={Naravat Poungvarin and Benny H-J Chang and Minako Imamura and Junsheng Chen and Kanya Moolsuwan and Chanachai Sae-Lee and Wei Li and Lawrence K Chan},
  journal={Endocrinology},
  year={2015},
  volume={156 6},
  pages={1982-94}
}
Glucose is an essential nutrient that directly regulates the expression of numerous genes in liver and adipose tissue. The carbohydrate response element-binding protein (ChREBP) links glucose as a signaling molecule to multiple glucose-dependent transcriptional regulatory pathways, particularly genes involved in glycolytic and lipogenic processes. In this study, we used chromatin immunoprecipitation followed by next-generation sequencing to identify specific ChREBP binding targets in liver and… CONTINUE READING
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