Genome Wide Analysis of Acute Myeloid Leukemia Reveal Leukemia Specific Methylome and Subtype Specific Hypomethylation of Repeats

@inproceedings{Saied2012GenomeWA,
  title={Genome Wide Analysis of Acute Myeloid Leukemia Reveal Leukemia Specific Methylome and Subtype Specific Hypomethylation of Repeats},
  author={Marwa H. Saied and Jacek Marzec and Sabah Khalid and Paul R Smith and Thomas A. Down and Vardhman K. Rakyan and Gael Molloy and Manoj Raghavan and Silvana Debernardi and Bryan D. Young},
  booktitle={PloS one},
  year={2012}
}
Methylated DNA immunoprecipitation followed by high-throughput sequencing (MeDIP-seq) has the potential to identify changes in DNA methylation important in cancer development. In order to understand the role of epigenetic modulation in the development of acute myeloid leukemia (AML) we have applied MeDIP-seq to the DNA of 12 AML patients and 4 normal bone marrows. This analysis revealed leukemia-associated differentially methylated regions that included gene promoters, gene bodies, CpG islands… CONTINUE READING
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