Genome-Wide Analysis and Functional Characterization of the Polyadenylation Site in Pigs Using RNAseq Data

@inproceedings{Wang2016GenomeWideAA,
  title={Genome-Wide Analysis and Functional Characterization of the Polyadenylation Site in Pigs Using RNAseq Data},
  author={Hongyang Wang and Rui Li and Xiaoping Zhou and Liyao Xue and Xuewen Xu and Bang Liu},
  booktitle={Scientific reports},
  year={2016}
}
Polyadenylation, a critical step in the production of mature mRNA for translation in most eukaryotes, involves cleavage and poly(A) tail addition at the 3' end of mRNAs at the polyadenylation site (PAS). Sometimes, one gene can have more than one PAS, which can produce the alternative polyadenylation (APA) phenomenon and affect the stability, localization and translation of the mRNA. In this study, we discovered 28,363 PASs using pig RNAseq data, with 13,033 located in 7,403 genes. Among the… CONTINUE READING

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